TNFR superfamily trimers
نویسندگان
چکیده
منابع مشابه
Characterization of chicken TNFR superfamily decoy receptors, DcR3 and osteoprotegerin.
Tumor necrosis factor (TNF) family ligands bind to death domain-containing TNF receptors (death receptors), which can subsequently activate intracellular signaling pathways to initiate caspase activity and apoptotic cell death. Decoy receptors, without intracellular death domains, have been reported to prevent cytotoxic effects by binding to and sequestering such ligands, or by interfering with...
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TNFR superfamily (TNFRSF)4 (OX40, CD134) and TNFRSF25 are costimulatory receptors that influence CD4(+) and CD8(+) T cell responses to cognate Ag. Independently, these receptors have been described to stimulate overlapping functions, including enhanced proliferation and activation for both regulatory T cells (CD4(+)Foxp3(+); Tregs) and conventional T cells (CD4(+)Foxp3(-) or CD8(+)Foxp3(-); Tco...
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Tumor necrosis factor receptor (TNFR) superfamily members mediate the cellular response to a wide variety of biological inputs. The responses range from cell death, survival, differentiation, proliferation, to the regulation of immunity. All these physiological responses are regulated by a limited number of highly pleiotropic kinases. The fact that the same signaling molecules are involved in t...
متن کاملRegulation of Tissue Responses: The TWEAK/Fn14 Pathway and Other TNF/TNFR Superfamily Members That Activate Non-Canonical NFκB Signaling
The immune system mediates tissue responses under both physiological and pathological conditions. In addition to leukocyte subsets, non-hematopoietic tissue cell types actively contribute to shaping tissue responses, including the inflammatory, fibrogenic, and regenerative components. TWEAK and its receptor Fn14, members of the TNF/TNFR superfamily, have emerged as a prominent molecular axis re...
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The receptors and ligands in this superfamily have unique structural attributes that couple them directly to signaling pathways for cell proliferation, survival, and differentiation. Thus, they have assumed prominent roles in the generation of tissues and transient microen-capabilities are crucial in coordinating the proliferation and protective functions of pathogen-reactive cells. Here, we re...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2006
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd1952